- Downingtown Borough
- The old center, and the only part of the ZIP where floodplain rules come up regularly. Well-kept 1930s twins near the middle, oil-heated Cape Cods off East Lancaster Avenue, and the usual older-house list waiting behind the plaster. If the parcel sits inside a mapped floodplain, a permit is required before any construction at all, interior work included.
- East Caln Township
- Wraps the eastern half of the borough. On the street you cannot tell where one stops and the other starts. Condominiums through to large single-family homes, plus the Brandywine Square shopping area. Scope varies house to house more than anywhere else in the ZIP.
- Caln Township
- East along Lancaster Avenue toward Coatesville. Older suburban housing and apartments. Small kitchens, original bathrooms.
- East Brandywine Township
- North of the borough, built out through the nineties and 2000s on what used to be farmland. A lot of tall unfinished basements sitting under those houses.
- West Brandywine Township
- More rural again. Bigger lots, more wells and septic, and a longer run between stops.
- West Bradford Township
- South toward Marshallton. Subdivisions mixed with open ground, and older stone houses scattered through the western end.
- Uwchlan Township
- Lionville and the Exton edge. Dense by local standards, mostly eighties and later, with townhouses and carriage homes alongside the colonials.
- Upper Uwchlan Township
- North toward Marsh Creek, and the newest housing in the ZIP. Applecross and the developments around the state park. Big houses, square framing, and basements left bare for whoever bought the place.